Alzheimer's disease and related disorders annual, 2002 - download pdf or read online

By Jeffrey L Cummings, Serge Gauthier

ISBN-10: 1841842346

ISBN-13: 9781841842349

Given the advance of latest healing techniques and items, Serge Gauthier and Jeffrey Cummings have compiled an inventory of latest subject matters with a view to be of curiosity basically to neurologists concentrating on Alzheimer's illness, and in addition to psychiatrists and geriatricians. The participants, all revered of their subspecialties, have written updated, comprehensively referenced chapters which should supply information in addition to stimulate dialogue on the place present remedy is heading.

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Extra resources for Alzheimer's disease and related disorders annual, 2002

Sample text

Impairments of long-term potentiation in hippocampal slices of beta-amyloid-infused rats. Eur J Pharmacol 1999; 382:167–175. 61. Moran PM, Higgins LS, Cordell B, Moser PC. Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human beta-amyloid precursor protein. Proc Natl Acad Sci USA 1995; 92:5341–5345. 62. Yamaguchi F, Richards SJ, Beyreuther K et al. Transgenic mice for the amyloid precursor protein 695 isoform have impaired spatial memory. Neuroreport 1991; 2:781–784.

A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 1992; 356:768– 774. 14. Rossiter JP, Anderson LL, Yang F, Cole GM. Caspase-cleaved actin (fractin) immunolabelling of Hirano bodies. Neuropathol Appl Neurobiol 2000; 26:342–346. 15. Gervais FG, Thornberry NA, Ruffolo SC et al. Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide. J Biol Chem 1998; 273: 17102–17108. 16. Milligan CE. Caspase cleavage of APP results in a cytotoxic proteolytic peptide.

Activated caspase-3 expression in Alzheimer’s and aged control brain: correlation with Alzheimer pathology. Brain Res 2001; 898:350–357. 34. Stefanis L, Park DS, Yan CY et al. Induction of CPP32-like activity in PC12 cells by withdrawal of trophic support. Dissociation from apoptosis. J Biol Chem 1996; 271:30663– 30671. 35. Troy CM, Stefanis L, Greene LA, Shelanski ML. Nedd2 is required for apoptosis after trophic factor withdrawal, but not superoxide dismutase (SOD1) downregulation, in sympathetic neurons and PC12 cells.

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